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Title

INTERACTION BETWEEN HER-2 AND HORMONE RECEPTORS IN BREAST CANCER

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 Start Page 7 | End Page 11

Abstract

 Introduction: The most common malignancy, with more than one million new case per year in the world, is BREAST CANCER. The progression of BREAST CANCER in human is mostly regulated with steroidal hormones such as estrogen and peptide growth factors which are interacted with epidermal growth factor 1 and 2. HORMONE RECEPTORS level is low in normal breast tissue but high in two third of BREAST CANCER.Material and Methods: In this study, 237 patients who had referred to the oncology clinic of Tabriz University of Medical Sciences with diagnosis of BREAST CANCER (from 1382 through 1388) were involved. The variant data was extracted from the medical record. Data was analyzed by SPSS software and proper statistical examination.Results: From the total of 237 patients, 50.6% were ER+, 48.9% were PR+ and 37.1% were HER-2+. The greatest percentage of HER-2+(51.6%) was in the ages over 60 and the least in the group age 31-40 yrs. The greatest percentage of HR+(71%) was also in patients over 60 and the least (50%) in patients less than 30. 35.5% of patients in pre-menstrual period were HER-2+, at the time that HR+ percentage was 64% in LN+ patients, percentage of HER-2+ and HR+ was 35.4% and 65.4% while in LN- patients it was 39% and 61.9% respectively. The greatest positive rate of HER-2 was at stage I and HR+ was related to stage IV.Discussion: Acquired data showed to be in inverse ratio between the rate of expression of epidermal growth factor II and HORMONE RECEPTORS in BREAST CANCER. 40-55% of samples with expression of epidermal growth factors lacked HORMONE RECEPTORS. Existence of both HORMONE RECEPTORS and expression of HER-2 in BREAST CANCER are considered as important prognostic factors.

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