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Title

THE RELATIONSHIP BETWEEN PLASMA ADIPONECTIN CONCENTRATION AND ANTHROPOMETRIC AND BIOCHEMICAL VARIABLE IN TEHRAN LIPID AND GLUCOSE STUDY

Pages

  69-74

Abstract

 Aim/Background: ADIPONECTIN plays an important role in the genetic predisposition to OBESITY, and insulin resistance. The aim of this investigation was to determine the probable relationships of fasting ADIPONECTIN level and anthropometric and biochemical variable in 343 subjects.Materials and methods: Three hundred forthy three including 163 males and 180 females, participated in THE TEHRAN LIPID AND GLUCOSE STUDY who were randomly divided into four groups, each group consisted of 83, 84, 87 and 89 subjects respectively, according to the BODY MASS INDEX, (BMI<20, 20£ BMI<25.25£ BMI<30, BMI>30). Fasting Blood Sugar (FBS), HDL-C, HDL-C, triglyceride, total cholesterol and ADIPONECTIN levels were determined. Data were compared statistically by Mann- Whitney and kruskal-Wallis tests. In order to assess the relationship between ADIPONECTIN and biochemical and anthropometric variable, the Correlation Coefficient Spearman was used. All data were analyzed using SPSS, version 15.Results: There was a significant difference between ADIPONECTIN level in men and women and it was lower in men. There was a significant difference between waist to hip ratio, waist and hip BMI and FBS, Cholesterol, TG, HDL-C and LDL of men and women. There was also a significant difference in the level ADIPONECTIN in overweight and obese groups compared with other groups. ADIPONECTIN had a negative association with waist and hip circumference and waist to hip ratio waist, BMI and TG, and a positive association with HDL-C.Conclusion: The association of ADIPONECTIN with anthropometric and biochemical variable has been confirmed. Low adipose tissue ADIPONECTIN expression observed in obese people may contribute to the progression of OBESITY. Finally, the results show that the ADIPONECTIN expression from adipose tissue is higher in lean subjects and women.

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