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Title

CAUDAL EXTRADURAL ANALGESIA WITH LIDOCAINE, XYLAZINE, AND A COMBINATION OF LIDOCAINE AND XYLAZINE IN THE IRANIAN RIVER BUFFALO (BUBALUS BUBALIS)

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 Start Page 7 | End Page 13

Abstract

 Objective: To compare the time of onset, duration of action and the extent of analgesia produced by a LIDOCAINE/xylazine combination with that produced by LIDOCAINE and XYLAZINE alone after injection into the caudal extradural space of the Iranian river BUFFALO.Design: Observer-blind prospective descriptive trial, Latin square design.Animals: Eleven adult (aged over 2 years) female non-gravid healthy Iranian river BUFFALOes (Bubalus bubalis), weighing from 450 to 650 kg.Procedure: CAUDAL EXTRADURAL ANALGESIA was achieved in BUFFALOes on 3 occasions at 14-day intervals by injection of 2% LIDOCAINE (L; 0.22 mg kg-1), 2% XYLAZINE (X; 0.05 mg kg-1), and a combination of 2% LIDOCAINE(0.22 mg kg-1) / 2% XYLAZINE (LX; 0.05 mg kg-1) in a Latin square design. Analgesia was determined by the lack of response to pin-prick and haemostat pressure in the skin of the caudal areas.Results: Onset of analgesia for X was significantly longer (5.5±0.7 minutes) than that for L or LX. Duration of analgesia was significantly longer for LX (172.3±17.7 minutes) than for either drug used alone (LIDOCAINE, 79.5±5.7 minutes; XYLAZINE, 136.4±11.4 minutes). In X and LX groups, the level of analgesia ascended to thoracic segments; however, in LIDOCAINE-treated BUFFALOes thighs, flank, and udders remained sensitive. In all BUFFALOes, XYLAZINE, administered either alone or with LIDOCAINE, induced mild to moderate ataxia.Conclusions: The LX combination provided a more rapid onset, a longer duration of analgesia, and a more cranial spread of analgesic effect compared with either drug alone. Clinical relevance: The LX combination may offer a fast and long lasting anesthesia/analgesia to perform obstetrical and surgical procedures without the need for reinjection.

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