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Journal: JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL | Year:1388 | Volume:8 | Issue:1 (60) | Start Page:10 | End Page:17

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Title

SERUM HUMAN CHORIONIC GONADOTROPIN AS A PREDICTOR OF OUTCOME IN ASSISTED REPRODUCTIVE TECHNOLOGY PREGNANCIES

Pages

 Start Page 10 | End Page 17

Abstract

 Objective: ASSISTED REPRODUCTION TREATMENT (ART) entails a risk of ECTOPIC PREGNANCY and early pregnancy loss. Serum ß-human chorionic gonadoropin (b-hcg) has been found to be predictive of PREGNANCY OUTCOME. Our aim was to determine whether serum b-hcg levels obtained 16 days after ovulation are reliable predictors of PREGNANCY OUTCOME.Subjects and Methods: In this retrospective study, 200 women who have achieved a pregnancy through ART treatment at the INFERTILITY clinic of Mashhad Medical Sciences University were evaluated. The treatment included IUI in 196 (98%), ICSI in 2 (1%) and IVF in 2 (1%). Serum samples were obtained on days 16 and serum b-hcg concentration was measured by immune-radiometric assay.Results: The mean age at treatment was 29 (range 19-35 y). One hundred and sixty women aged above 30 y and 40 cases aged below 30 y .Out of 200 patients with ART cycles 175 cases were found to be viable pregnancies (live fetus at 20 weeks gestation) and 25 patients resulting in spontaneous abortion. A statistically significant difference was found between the mean b-hcg value of the non-viable and viable pregnancies (P<0.001).Conclusions: A single serum b-hcg level 16 days after ovulation provides a useful predictor of PREGNANCY OUTCOME.

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