A Study of Autoantibodies against Some Central Nervous System Antigens and the IL-35 Serum Level in Schizophrenia

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Soltani Marziyeh; Beshkar Pezhman; Mokhtarian Kobra; ANJOMSHOA MARYAM; Mohammad Rezaei Mina; AZADEGAN DEHKORDI FATEMEH; Mirzaei Yousef; MAJIDI JAFAR; BAGHERI NADER

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Journal: Iranian Journal of Allergy, Asthma and Immunology Year:2022 | Volume:21 | Issue:4 Page(s): 441-448

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Title

A Study of Autoantibodies against Some Central Nervous System Antigens and the IL-35 Serum Level in Schizophrenia

Author(s)

Keywords

Autoantibodies

Interleukin 35 microglia

Neurogenic inflammation

Schizophrenia

Abstract

Schizophrenia (SCZ) is a debilitating mental disorder with various causes involving complex interactions between genetic factors and environmental agents. The immune system plays a vital role in the pathology and function of the nervous system. Interleukin 35 (IL-35) is a regulatory and anti-inflammatory cytokine that can prevent autoimmune and inflammatory diseases. This study aimed to investigate the role of Autoantibodies against some central nervous system (CNS) antigens and IL-35 serum levels in patients with Schizophrenia. This case-control study involved 80 participants. The serum levels of IL-35 were measured by enzyme-linked immunosorbent assay and the Autoantibodies in the CNS by indirect immunofluorescence assay (IFA). The serum levels of IL-35 were decreased in patient groups compared to healthy subjects. Autoantibodies against N-methyl-D-aspartate receptor (NMDAR) and myelin-associated glycoprotein (MAG) were positive in 15% (6/40) and 7. 5% (3/40), respectively,however, no antibodies against myelin, aquaporin-4 (AQP4), myelin oligodendrocyte glycoprotein (MOG), voltage-gated potassium channel (VGKC), α,-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPAR), γ,-butyric acid receptor type B1 γ,-butyric acid receptor type B1 (GABABR), antidipeptidyl peptidase-like protein-6 (DPPX), immunoglobulin-like cell adhesion molecule 5 (IgLON5), Glycine receptor (R) and acetylcholine receptor (Ach R) were detected (No statistics were computed). We found that decreased serum IL-35 levels and the existence Autoantibodies against NMDAR antigen may contribute to the pathogenesis of SCZ.

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APA: Copy

Soltani, Marziyeh, Beshkar, Pezhman, Mokhtarian, Kobra, ANJOMSHOA, MARYAM, Mohammad Rezaei, Mina, AZADEGAN DEHKORDI, FATEMEH, Mirzaei, Yousef, MAJIDI, JAFAR, & BAGHERI, NADER. (2022). A Study of Autoantibodies against Some Central Nervous System Antigens and the IL-35 Serum Level in Schizophrenia. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 21(4), 441-448. SID. https://sid.ir/paper/1076938/en

Vancouver: Copy

Soltani Marziyeh, Beshkar Pezhman, Mokhtarian Kobra, ANJOMSHOA MARYAM, Mohammad Rezaei Mina, AZADEGAN DEHKORDI FATEMEH, Mirzaei Yousef, MAJIDI JAFAR, BAGHERI NADER. A Study of Autoantibodies against Some Central Nervous System Antigens and the IL-35 Serum Level in Schizophrenia. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2022;21(4):441-448. Available from: https://sid.ir/paper/1076938/en

IEEE: Copy

Marziyeh Soltani, Pezhman Beshkar, Kobra Mokhtarian, MARYAM ANJOMSHOA, Mina Mohammad Rezaei, FATEMEH AZADEGAN DEHKORDI, Yousef Mirzaei, JAFAR MAJIDI, and NADER BAGHERI, “A Study of Autoantibodies against Some Central Nervous System Antigens and the IL-35 Serum Level in Schizophrenia,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 21, no. 4, pp. 441–448, 2022, [Online]. Available: https://sid.ir/paper/1076938/en

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