Background and Aim: Given the growing trend of researches, the purpose of this study was to explain the effectiveness of this training and its effective factors. Materials and Methods: The present study is a mixed and explanatory project. In the first step, the quantitative meta-analysis method was used to determine the effectiveness of self-care education and in the second step, the qualititative method was applied to examine its effective factors. The statistical population of the first stage included all related internal research and the second stage comprised all cardiologists in Isfahan province. The data collection tool was a researcher-made checklist in the first stage and a semi-structured interview method for the second stage. Comprehensive statistical meta-analysis software(CMA) Version II was used to analyze the first stage data; for the second stage, coding methods were applied. Results: The results showed that self-care education interventions were highly effective in cardiac patients(ES=1. 616, P<0. 05). In other words, the average effectiveness of self-care education in the experimental groups was 94% more than that of the control groups. Besides, the results of the second stage showed that there were seven factors affecting effectiveness: teachability, personal control, physical activity, nutrition, emotion control, optimism, and continuous follow-up. Conclusion: Based on the above-mentioned factors, self-care is the most effective one in controlling and improving Heart diseases, which will lead to a longer life expectancy and a better quality of life for Heart patients.