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مرکز اطلاعات علمی SID1
مرکز اطلاعات علمی SID
مرکز اطلاعات علمی SID
مرکز اطلاعات علمی SID
مرکز اطلاعات علمی SID
مرکز اطلاعات علمی SID
مرکز اطلاعات علمی SID
Writer: 

SHARIFIAN MOSTAFA

Issue Info: 
  • Year: 

    2012
  • Volume: 

    6
  • Issue: 

    3
  • Start Page: 

    1
  • End Page: 

    7
Measures: 
  • Citations: 

    0
  • Views: 

    14523
  • Downloads: 

    7618
Keywords: 
Abstract: 

PLEASE CLICK ON PDF TO VIEW THE ABSTRACT.

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Issue Info: 
  • Year: 

    2012
  • Volume: 

    6
  • Issue: 

    3
  • Start Page: 

    15
  • End Page: 

    19
Measures: 
  • Citations: 

    0
  • Views: 

    15874
  • Downloads: 

    7599
Keywords: 
Abstract: 

Objective: Serial seizures occur commonly in inpatient epileptic children. This type of seizure due to its characteristics has a significant impact on the patient’s health.Untreated serial seizures lead to status epilepticus; therefore, finding a more effective treatment for such patients is essential. This study was performed to compare the outcome of intermittent intravenous diazepam in the pediatric neurology clinic and intravenous midazolam in the pediatric intensive care unit (PICU), in order to introduce an alternative treatment for serail seizures.Materials & Methods: In this study, 38 inpatient children aged 6 mo-15 years with refractory serial seizures were treated by first line antiepileptic drugs and then randomly treated with either intermittent intravenous diazepam in the neurology ward or intravenous midazolam in PICU.Results: Fourteen (70%) diazepam group patients and 13 (72.2%) midazolam group patients had good response to treatment, there was no significant difference between the two groups. Four midazolam group patients and two diazepam group patients needed mechanical ventilation and were intubated during treatment, with no significant difference between the two groups. Durations of mechanical ventilation and PICU and hospital stay were not significantly different between the two groups.Conclusion: Intermittent intravenous diazepam is an effective alternative therapy for midazolam drip in the treatment of serial seizures due to similar therapeutic effects and fewer side effects.

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Issue Info: 
  • Year: 

    2012
  • Volume: 

    6
  • Issue: 

    3
  • Start Page: 

    21
  • End Page: 

    24
Measures: 
  • Citations: 

    0
  • Views: 

    16563
  • Downloads: 

    8768
Keywords: 
Abstract: 

Objective: Migraine is a disabling illness that causes absence from school and affects the quality of life. It has been stated that headache may represent an epileptic event. EEG abnormality is a prominent finding in children with migraine. The aim of this study was to evaluate EEG abnormalities in children with migraine.Materials & Methods: Two-hundred twenty-eight children were enrolled into the study.Evaluation and following of cases was performed by one physician, paraclinical tests were used to increase the accuracy. The study was conducted under the supervision of pediatric neurology masters and the selected cases were from different parts of the country.Results: Comparing EEG abnormalities in different types of migraine revealed that there is an association between them. There was also a significant difference between EEG abnormalities in different types of aura. Migraine type was associated with the patient’s age. Sleep disorders were more common in patients with a positive family history of seizure.Conclusion: Our study dos closed migraine as a common problem in children with abnormalities present in approximately20% of the patients. Migraine and abnormal EEG findings are significantly associated.

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Issue Info: 
  • Year: 

    2012
  • Volume: 

    6
  • Issue: 

    3
  • Start Page: 

    25
  • End Page: 

    31
Measures: 
  • Citations: 

    0
  • Views: 

    12959
  • Downloads: 

    13046
Abstract: 

Objective: Tuberous sclerosis complex is an autosomal dominant neurocutaneous disease that presents with dermatological, neurological, cardiac, renal and ocular symptoms.We described the variable clinical manifestations, neuroimaging findings, Age and sex distribution of tuberous sclerosis in a group of 81 patients referred to our clinic.Materials & Methods: Based on the diagnostic criteria, totally81 tuberous sclerosis patients with sufficient data were enrolled into the study. These children were referred by child neurologists.Results: The mean age of the patients was 52 months (range, 7-180 months). There were 28 girls and53 boys. A positive familial history of TSC was seen in 29.6% of the patients.Hypo pigmented macules were the most common manifestation (82.7%). Facial angiofibroma, shagreen patches, café-au-lait lesions and seizure were observed in 32.1%, 12.3%, 7.4%. and 74.1% of the studied cases, respectively. Infantile spasm was present in the clinical course of 32.1 % of the patients.Cortical tubers were the most common MRI finding which were seen in21 cases (25.9%). Subepandymal giant cell astrocytoma was seen in four (4.9%) patients and intracranial calcification (detected by CT scan) was observed in 18 (22.2%) of the patients.Conclusion Dermatological and neurological findings were the most common symptoms in tuberous sclerosis with a significant correlation between them. Thus, careful skin examination is necessary in epileptic patients for detection of the mentioned lesions.

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Issue Info: 
  • Year: 

    2012
  • Volume: 

    6
  • Issue: 

    3
  • Start Page: 

    33
  • End Page: 

    38
Measures: 
  • Citations: 

    0
  • Views: 

    15221
  • Downloads: 

    9683
Keywords: 
Abstract: 

Objective: The advent of computed tomography (CT) scan revolutionized the diagnostic evaluation of neurologic patients. The aim of this study was to evaluate brain CT results of epileptic children.Materials & Methods: In a descriptive cross-sectional study, noncontrast brain CT scan of 150 consecutive 1-18 year old epileptic children whom were referred to pediatric neurology clinic of Shahid Sadoughi University of Medical Sciences, from May 2008 to October 2010 in Yazd-Iran, evaluated.Results: Sixty two girls and 88 boys with mean age of 6.6±4.3 years were evaluated.In 38 (25.3%) children, seizure onset age was under one year and 38 others had abnormal mental / developmental status. Fifty three children (35.3%) and 97 (64.7%) had partial and generalized seizures, respectively. Partial seizures were more prevalent in children with seizure onset in<1 year [41.5% (22.53) vs.16.5% (16.97)] Result of CT was normal in 74% (n=111). Among the patients with abnormal results, 18 (46%) had brain atrophy, 10 (25.6%) structural CNS dysgenesia, six (15.4%) intracranial calcification, three (7.8%) hydrocephaly and two had (5.2%) brain tumor.Abnormal brain CT was more prevalent in patients with seizure onset in less than one year of age [60.5% (23 of 38) vs.14.3% (16 of 112), p=0.003], partial epilepsy [51% (27 of 53) vs.12% (12.97)], and abnormal developmental status [81.5% (31 of 38) vs.7% (8 of 112]. Mean age of seizure onset in epileptic children with abnormal brain CT scan was less (M±SD: 1.17±0.6 years versus 4.02±1.9 years).Conclusion: Brain CT scan might be considered in evaluation of epileptic children with partial seizures, seizure onset in less than one year of age or neurodevelopmental delay.

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Issue Info: 
  • Year: 

    2012
  • Volume: 

    6
  • Issue: 

    3
  • Start Page: 

    39
  • End Page: 

    43
Measures: 
  • Citations: 

    0
  • Views: 

    14376
  • Downloads: 

    13942
Abstract: 

Oculodentodigitalis dysplasia (ODDD) is an extremely rare inherited disorder involving the development of the face, eyes, teeth and limbs. In addition, some patients develop neurological problems mostly a spastic paraparesis associated with white matter abnormalities on magnetic resonance imaging. This report describes a patient with epilepsy, a rare neurologic manifestation of this syndrome.

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Issue Info: 
  • Year: 

    2012
  • Volume: 

    6
  • Issue: 

    3
  • Start Page: 

    45
  • End Page: 

    48
Measures: 
  • Citations: 

    0
  • Views: 

    14958
  • Downloads: 

    13912
Keywords: 
Abstract: 

Congenital insensitivity to pain and anhidrosis (CIPA) or hereditary sensory autonomic neuropathies type IV (HSAN type IV) is an extremely rare autosomal recessive disorder initially described by Swanson in 1963.We report a 2.5-year-old boy with clinical features of CIPA as the first case in Iran.The symptoms included recurrent episodes of hyperthermia and unexplained fever that began in early infancy, anhidrosis (inability to sweat), profound loss of pain sensitivity, neurodevelopmental delay, unconscious self-mutilation of fingers, lips and tongue, corneal lacerations, palmar hyperkeratosis, non-painful fracture and joint deformities in the right ankle. Tearing, deep tendon reflexes and motor and sensory nerve action potentials were normal.Prenatal screening is the sole accessible option to prevent the birth of an affected child as no cure is available. Early recognition of CIPA patients and its orthopedic complications, prevention of accidental injuries, regular visual and eye follow-up and specific dental management could be useful in the reduction of frequency and severity of complications.

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Issue Info: 
  • Year: 

    2012
  • Volume: 

    6
  • Issue: 

    3
  • Start Page: 

    9
  • End Page: 

    13
Measures: 
  • Citations: 

    0
  • Views: 

    12434
  • Downloads: 

    7929
Keywords: 
Abstract: 

Objective: Hyperglycemia may occur in the patients affected by any kind of critical illness.This complication makes an adverse effect on the clinical outcome of these patients by causing polyneuropathy and myopathy. It has been recently shown that treatment of hyperglycemia with insulin administration significantly reduces the prevalence of critical illness polyneuropathy and myopathy (CIPNM) and on the other hand reduces the demand for long-term mechanical ventilation in the patients admitted to the ICU for more than 1 week. The aim of this study was to determine the therapeutic effect of insulin in reducing the incidence of CIPNM in the pediatric intensive care unit (PICU).Materials & Methods: In this study, we recruited 30 patients admitted to the PICU of Tabriz Pediatric Hospital. The incidence of CIPNM following hyperglycemia was evaluated in these patients. The patients were categorized into two groups. In the case group, blood sugar was controlled in the range of 140-180 mg/dl by administration of 0.05 unit per kilogram body weight of insulin as drip protocol in an hour and in the control group, placebo was used. Consequently, the incidence of CIPNM, duration of PICU and duration of mechanical ventilation were compared between the two groups.Results: The incidence of CIPNM and duration of PICU stay and mechanical ventilation were significantly reduced in the patients treated with insulin compared to the control group.Conclusion: This study shows that blood sugar control decreases the incidence of CIPNM.

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