Economic changes in Europe, competition of European monarchs to find an ally against the Ottoman empire, recognition of Shiism, and safavid monarches' welcoming of the presence of Europeans in Iran led to their widespread presence in Isfahan. European travelers such as explorers, ambassadors, missionaries and etc. during their stay in Iran, recorded part of the written history of the Safavid government by reporting the events of those days in their itineraries. These studies suggest their views of different aspects of the history and culture of the Safavid era. Meanwhile, the major concern of the study is to investigate the garments of Safavids in itineraries and their correspondence with Safavids paintings, particularly with the school of Isfahan. To examine this question and its hypotheses, the most important itineraries written in this period were studied and compared with the paintings of the school of Isfahan. Also, the evolution of garments was necessarily evaluated and a comparison was made between the garments of early and late Safavid. As we know, due to the influence of political, social, and cultural circumstances, Safavid era painting was different from the period before and after it. It was therefore affected by the satisfaction of rulers, customers, and supporters of art and generally reflected in the images of the characters and their cover. As a result, it was determined that European itineraries, especially with the paintings of this period, can be a reliable source of clothing in the Safavid period.