Tribulus terrestris is a one-year-old herb dispersed in hot and humid areas in the Mediterranean and warm regions of Europe, Asia, Africa and Australia. This plant has many benefits and is used in traditional medicine for the treatment of various diseases, including kidney stones, low blood pressure, anti-diabetic properties, and treatment of cardiovascular diseases, gastrointestinal disorders, and sexual performance in men and in treatment of hepatitis is recommended. The aim of this study was to investigate the pharmacological and therapeutic properties of pharynx in traditional medicine and scientific papers in modern medicine. This study is a systematic review based on the PRISMA checklist. Based on keywords, 440 titles were selected and after removing repetitive articles, 129 papers were extracted from various databases including PubMed, SID, ScienceDirect, Scopus and Magiran, and the Google Scholar search engine without time limit. T. terrestris has several properties, including antimicrobial, antibacterial, free radicals purification and inhibition of lipid peroxidation, and through various mechanisms of cell and molecules, it produces various pharmacological and therapeutic properties. One of the most important therapeutic properties of this plant is its antiinflammatory and anti-cancer properties. Also, several clinical studies have shown that coadministration of tetanus extract with chemotherapy drugs reduces the side effects of drugs. Due to the lack of toxicity and side effects of T. terrestris, the use of herbs has been considered as a complementary drug in diet regimens for various diseases.