diarrheal diseases accounted for about 4.6 million deaths from around 1 billion episodes of illness annually in children younger than 5 years of age. A decade later, even without significant change in incidence, the number of deaths attributable to diarrheal diseases decreased to 3.3 million per year. Probiotics administered as supplemental medicinal agents are likely to decrease the duration of acute infectious gastroenteritis in about 24 h.Article used in this study, were collected by searching in informative bank such as web of knowledge, Science direct, willy and Scopus, The keywords probiotics, infection, childern, diarrhea, Lactobacillus and Bifidobacreium were used for searching. Published date of articles was between 1995 to 2012.Literature shows a statistically significant but clinically modest benefit for some Lactobacillus strains, mainly in infants and young children, in the treatment of acute watery diarrhea, especially in rotavirus gastroenteritis. Most studies of probiotics in the management of acute diarrhea have been conducted in relatively healthy and stable populations. While a distinction between different probiotic agents is made, little emphasis thus far is given to different probiotic dosages (CFU/ml) used in studies, even among the same probiotics, and that needs to be considered in the assessment of efficacy.Because most of the probiotic research has been conducted in rotaviral diarrhea, a future research agenda should include assessment of efficacy and effectiveness in diarrheal illnesses caused by other enteric pathogens, especially bacteria.