An association between human infertility and chromosomal abnormalities has been known for a long time. The incidence of karyotype abnormalities among infertile couple has been reported and thus it would not be unusual to find chromosomal abnormalities in men or women attending an infertility clinic. Karyotyping of white blood cells of every couple attending the infertility clinic would be necessary to indentify to identify those with genetic defect.
The objective of this study was to examine 3 groups of couples from infertile marriages in and attempt to identify any karyotype abnormality that could be of predictive value for infertility. 3 groups are: Familial marriage, recurrent spontaneous abortion and IVF failure. Cytogenetic analysis performed on 30 couples of every group showed any significant different in abnormalities among these patients. Other studies have indicated that deletion on the long arm of Y chromosome may lead to azoospermia. A relationship between balanced autosomal translocations and infertility has been reported and an association between autosomal inversion and infertility has been reported. These inversions may cause problems at meiotic division which will disrupt cell division and thus reduse oogenes is or spermatogenesis.
At least, we suggest that karyotyping and genetic counetic counseling both partners should be recommended routinely prior to a ARTs, treatment.