مشخصات

عنوان:

Congenital Hypothyroidism as the main cause of G6PD deficiency phenotype in neonates



گروه تخصصی:  پزشکی

سازمان مجری:  واحد استان فارس 

گروه پژوهشی: زیست شناسی سلولی مولکولی

پژوهشگران: 
سنمار سارا (مسئول طرح)

تاریخ خاتمه:  اسفند 1386

کارفرما: جهاددانشگاهی فارس

خروجی طرح: 

ارائه نتیجه طرح به کارفرما


نوع: کاربردی

 
تلفن: 2335010-0711

نشانی سازمان مجری: شیراز، خیابان زند، دانشکده پزشکی، حوزه مدیریت جهاددانشگاهی فارس،صندوق پستی: 1463-71345
 

چکیده:

Glucose-6-phosphate dehydrogenates (G6PD) deficiency is the most common defects of red blood cells among Iranian and Mediterranean people. Hypothyroidism is defined as thyroid hormone deficiency starting from the time of birth. Thyroid hormones influence the activity of lipogenic enzymes such as glucose-6-phosphate dehydrogenase and malic enzyme.
This study aimed to determine the rate of hypothyroidism in patients with G6PD deficiency. After 120 days, the newborns that administered drug and diet for hypothyroidism were checked for TSH and G6PD enzyme.
2287 out of 23260 screened babies were afflicted with favism (512 females and 1775 males). 42 cases were hypothyroid among who 35 had G6PD deficiency. However, after 120 days of treatment with Levothyroxine, 23(85%) patients of them had normal levels of G6PD.It shows that their deficiency had no genetic origin.
Base on these findings of this study, the newborns with G6PD deficiency should be checked for thyroid hormones. Moreover, in the hypothyroid patients, checking the level of G6PD is recommended.



کلیدواژگان:

 
 
Title:

Congenital Hypothyroidism as the main cause of G6PD deficiency phenotype in neonates



Abstract:

Glucose-6-phosphate dehydrogenates (G6PD) deficiency is the most common defects of red blood cells among Iranian and Mediterranean people. Hypothyroidism is defined as thyroid hormone deficiency starting from the time of birth. Thyroid hormones influence the activity of lipogenic enzymes such as glucose-6-phosphate dehydrogenase and malic enzyme.
This study aimed to determine the rate of hypothyroidism in patients with G6PD deficiency. After 120 days, the newborns that administered drug and diet for hypothyroidism were checked for TSH and G6PD enzyme.
2287 out of 23260 screened babies were afflicted with favism (512 females and 1775 males). 42 cases were hypothyroid among who 35 had G6PD deficiency. However, after 120 days of treatment with Levothyroxine, 23(85%) patients of them had normal levels of G6PD.It shows that their deficiency had no genetic origin.
Base on these findings of this study, the newborns with G6PD deficiency should be checked for thyroid hormones. Moreover, in the hypothyroid patients, checking the level of G6PD is recommended.



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