The ovulation disorders and unexplained infertility are of the most common causes of female infertility. The first line treatment in these cases is the administration of clomiphene citrate. This study has been designed to evaluate the time necessary for the growth of follicles to reach 18mm of diameter in patients who were stimulated to ovulate with clomiphene citrate. In this experimental study 170 women with polycystic ovary syndrome (PCO) or unexplained infertility referring to Royan Research Center consisted the cases. This group were treated with 100mg clomiphene citrate from the day 5 to 9 of their menstrual cycle. Follicle growth monitoring was persormed by vaginal ultrasonography. The period of time necessary for follicles to grow and reach a diameter of 18mm in both groups of PCO and unexplained infertility was separately determined and its association with age, duration of infertility, BMI and hirsutism was studied in both groups.
In this study the average time of folliculogenesis didn't have statistically significant difference, and in both groups was the 14th day of menstrual cycle and did not have a significant association with age, duration of infertility, hirsutism and BMI.
No responsiveness to clomiphene, as non-growing follicles or midluteal progestron less than 5ng/ml was more common in patient with polycystic ovary syndrome.