Background: Premature coronary heart disease (PCAD) is under the influence of environmental and genetic factors. Upstream transcription factor 1 (USF1) is a ubiquitously expressed transcription factorcontrolling several critical genesin lipid and glucose metabolism. Of some 40 genes regulated by USF1, several are involved in the molecular pathogenesis of cardiovascular diseases. Also this gene co-localized with familial combined hyperlipidemia (FCHL) and type 2 diabetes which predispose to early CVD. In this study we examined the previously identified risk polymorphisms of USF1 with respect to PCAD and its related phenotypes in population of south of Iran.
Material and method: two polymorphism of USF1gene was genotyped in 392 individual with PCAD (with significant atherosclerosis in angiographic results) and control cases (with no evidence of atherosclerosis in angiographic results) using PCR-RFLP method. A set of questionnaires administrated and serum factors was measured. Then statistical analysis including regression logistic and chi-square were performed on data.
Results: In our studied population, rs2073658 SNP was significantly associated with FBS levels (P=0.006). Individual with GG had higher FBS levels; but there was no correlation with PCAD or other serum factors. Relating to rs3737787 SNP also there were no significant differences in allelic frequencies between cases and control and it did not show any significant relation with any parameters (P>0.05).
Conclusion: USF1 gene can affect to the some related CVD traits in our south Iranian population but no significant association with increasing or decreasing PCAD risk.