Paper Information

Title: 

EFFECT OF METRONIDAZOLE ON RESPONSE TO CHOLINERGIC AGONIST OF CHARBACHOL IN RAT ILEUM

Type: POSTER
Author(s): BABAEI A.,MAHDAVI S.M.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Metronidazole had been used used in protozeal and anaerobic infections. There are also controvertial reports about effect of metronidazole on vascular and intestinal smooth muscles. In these regards there is a study indicating metronidazole enhance effect of histaminergic agonists on guinea pig ileum and there are also some reports about role of nitric oxide in antiprotozoal effect of metronidazole. In the basis of these reports in this study we evaluate the effect of metronidazole on carbachol induced contraction in rat ileum. This study was performed on segments of ileum (1 cm) by connecting it to an isotonic transducer and recording contractions by MD2 one channel recorder. At first the effect of different concentrations of metronidazole and charbachole (10-3 - 10-6 mol/L) were evaluated as asingle drug and in another way the effects of charbachol were evauated in the presence of metronidazole and metronidazole plus atropine. Additive concentrations of metronidazole (10-3 - 10-6 mol/L) does not affect ileum contrctions. Charbachol (10-3 - 10-6 mol/L) concentration dependently produced contraction in rat ilum. Metronidazole enhances responces to all concentrations of charbachol about 40% which was statistically significant (p< 0.05) but the effect of different concentrations of metronidazole on charbachol responce were not statistically significant (p<0.05). Maximal response to charbachol also increased by metronidazole. Atropine application blocked response to both of charbachol and charbachol plus metronidazole. Results of this study indicating another mechanism for metronidazole applicatoin in gastrointestinal obstractive deases.

 
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