Paper Information

Title: 

ANTINOCICEPTIVE EFFECT OF H2 RECEPTOR ANTAGONISTS IN HOT PLATE TEST IN MICE

Type: POSTER
Author(s): AHMADI A.,SAEIDI S.,KARAMI M.,EBRAHIMZADEH M.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Histamine is one of the inflammatory mediators that play a major role in inflammatory pain, because of presence of H receptors in spinal cord and their obvious stimulatory effect. H2 blocker such as cimetidine, ranitidine & famotidine are used in IC for their histamine blocking effect and helps in reducing ulcer pain. It was tried to investigate the effect of H2 receptor antagonists on nociception.
Material and method: The analgesic effect of cimetidine, ranitidine & famotidine as H2 blockers were evaluated using hot plate test in mice. Adult mice (25-30)g were used and latencies were recorded after (20, 40, 60) min when injected cimetidine, ranitidine & famotidine at all doses ip. Also the control animals and positive control group were received saline and morphine respectively.
Result the result show that hot plate latencies were increased when we administered cimetidine (50, 100, 200) mg/kg , ranitidine (25, 50, 100, 200) mg/kg & famotidine (5, 10, 20, 40) mg/kg. At higher doses cim (400 mg/kg), ran (400 mg/kg) & fam (80 mg/kg) we observed the severe symptoms of lethargy and anorexia as soon as the mice were injected. Also mortalities were occurred in all mice for famotidine at 80 mg/kg, 3 mice for cimetidine at 400 mg/kg and 3 mice for ranitidine at 400 mg/kg doses after 5 min of IP adminsterstion.
Discussion: histamine exists in brain as neurotransmitter or modulator and has a specific role on fluctuation on pain. Thus cimetidine, ranitidine & famotidine may cause a inhibitory effect on conduction of pain response by inhibition of histamine receptors.

 
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