Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Title: 

THE ANXIETY-RELATED BEHAVIORS OF THE BILATERAL HISTAMINE INJECTION IN THE RAT VENTRAL HIPPOCAMPUS USING AN ELEVATED PLUS-MAZE MODEL

Type: POSTER
Author(s): KHODARAHMI P.,ORYAN SHAHRBANOU,ZARINDAST M.R.,REZAYOF A.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: It has been indicated that histamine can affect anxiety-related behaviors in both animals and humans. There are also evidences that ventral hippocampus is an important brain site in the modulation of anxiety. In this study, the anxiety-related behaviors of the bilateral histamine injection at doses of 1.25, 2.5, 5 and 7.5 µg/rat, in a volume of 0.5µl in the ventral hippocampus of male adult rats were investigated.
Methods: In these experiments, animal weighting 200-250 at the time of surgery were used. Animal bilaterally cannulated in the ventral hippocampus by stereotaxic instrument, and were allowed to recover 1-week before behavioral testing. Eight animals were used in each group of experiments.
Results: We showed that histamine at doses of 7.5, 5, 2.5 µg/rat decreased the percent open arm time and also open arm entries, but not the locomotor activity. Conclusion: Therefore, our results indicated that injection of bilateral histamine in ventral hippocampus showing an anxiogenic response.

 
Keyword(s): 
 
 
Yearly Visit 50   tarjomyar
 
Latest on Blog
Enter SID Blog