Paper Information

Title: 

ANTI-MICROBIAL ACTIVITY OF SOME SCHIFF BASE FREE LIGANDS AND THEIR FE (III) DINUCLEAR COMPLEXES CONTAINING SALICYLALDEHYDE AND/OR SUBSTITUATED SALICYLALDEHYDE MOIETY

Type: POSTER
Author(s): ABNOUSI M.H.,KHAN MOHAMMADI H.,KEYPOUR H.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Schiff-base compounds have antimicrobial property.
Methods: A number of mononuclear and binuclear Schiff base ligands have been prepared by condensation reaction of, 4-Amino-3-(4-pyridyl)-5-mercapto-1,2,4-triazole with Salicylaldehyde and/or 4-Meyhoxy-salicyladehyde, in ethanol. The synthesized ligands, isolated as solids, were characterized by elemental analysis and spectroscopic methods. The dinuclear Iron (III) complexes of the prepared potentially dinuclear ligands also have been synthesized and characterized by spectroscopic methods. The newly prepared compounds were screened for their antibacterial and antifungal activity against Escherichia Coli (E.Coli), Staphylococcus (Stap h) aureus, and candida albicans (CA) strains using disc diffusion method. Muller-hinton and subro-dextrose agar for bacterial and fungal organisms respectively were kept at 37oC, 24 hrs and 27oC, 48 hrs. The inhibition zones were measured and compared with the control drugs.
Result: this study showed that five compounds (No. 8, 33, 35, 37, 40 and 41) out of 12 have antibacterial activity on Staphylococcus strain, and only compound 41 showed antibacterial activities on E.Coli. In this family of synthetic chemicals compounds No. 34, 35 and 37 were having antifungal activity.
Conclusion: these newly synthetic chemicals generally did not show a high antibacterial action (as compare to inhibition zone of standard drugs) on gram positive bacteria. But compound No. 35 with zone of inhibition of 24 as compare to nistatine (25 mm ZOI) was showing good anti-fungal activity. Thus this compound which can be synthesis as cost affordable chemical may be used as disinfectant where ever the CA is the main infectious agent.

 
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