Paper Information

Title: 

THE EFFECT OF CO-ADMINISTRATION OF EPINEPHRINE AND GLUCOSE ON SPATIAL LEARNING IN THE MALE RATS

Type: POSTER
Author(s): BELARAN M.*,MOAZEDI A.A.,HEMATI ALI ASGHAR,RASEKH A.A.R.
 
 *DEPARTMENT OF BIOLOGY, SCHOOL OF SCIENCE, SHAHID CHAMRAN UNIVERSITY OF AHVAZ
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: In young rats, extensive evidence indicates that circulating levels of epinephrine enhance memory and apparently does so, by increasing blood glucose levels. Also reports suggest that high doses of glucose haven't effect on learning while moderate doses of that improve memory. This study was designed to evaluate the influence of co-administered epinephrine and glucose on spatial learning.
Methods: Young male wistar rats were given daily injection of epinephrine (0.1 mg/kg 30 min before training, sc), glucose (500 mg/kg 10 min before training, i, p) and co-administration of epinephrine (0.1 mg/kg) and glucose (500 mg/kg).sham groups were received saline at the same volumes and conditions. A Y-maze apparatus was used.
Findings: The results showed that epinephrine significantly increase spatial learning in first (p<0.05), second (p<0.05), third (p<0.01) and fourth (p<0.05) days. Also, in glucose injection group spatial learning improve in first (p<0.05) day. Compare between co-administration of epinephrine and glucose with glucose injection group was significant in first day (p<0.001). On the other hand, compare between co-administered and glucose group wasn't significant.
Results: No synergic effect observed on spatial learning task in co-administration of epinephrine and glucose. It seems that in this condition, epinephrine enhances blood glucose levels and possibility this amount of endogenous glucose adds to exogenous glucose and impairs memory in compare with epinephrine or glucose groups.

 
Keyword(s): 
 
Yearly Visit 27   tarjomyar
 
Latest on Blog
Enter SID Blog