Paper Information

Title: 

THE STUDY OF THE EFFECT OF DESMOPRESSIN ON ANALGESIC EFFECT OF MORPHINE IN RAT

Type: POSTER
Author(s): BEYRAVANDI V.,ARZI A.,SARKAKI A.,BADAVI M.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Background: Desmopressin as a synthetic vasopressin analogue mainly used in treatment of diabetes insipidus and nocturia. The recent studies showed a high analgesic potency of desmopressin as compared with diclofenac in patients with acute renal colic.
Methods: This study was undertaken to determine the effect of desmopressin on analgesic effect of morphine in rat using tail flick test. At first
, analgesic effect of various doses of desmopressin (0.75, 1.5, 3g/kg,IP) were investigated. Then, the influence of these doses on the analgesic effect of suitable dose of morphine (2.5mg/kg,IP) were recorded. In addition to determine the role of opioid receptors on analgesic effect of desmopressin, one group of animals was treated with naloxone (1mg/kg,IP)15 minutes before receiving suitable dose (1.5μg/kg,IP) of desmopressin.
Findings: Results indicated that desmopressin has an analgesic effect in tail flick test. It also increased the analgesic effect of morphine and this effect was inhibited by naloxone
Conclusion: It is possible that desmopressin exerts its analgesic effect through opioid receptors or promotes the release of endogenous opiopeptides.

 
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