Paper Information

Title: 

EFFECT OF CHRONIC ADMINISTRATION OF HISTAMINE ON LITHIUM-INDUCED STATE DEPENDENT LEARNING IN MICE

Type: POSTER
Author(s): PARSAEI L.A.,ZARINDAST M.R.,BALOUCH M.,MADADI FAEZEH,LAHMI A.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

In the present study, Influence of sensitization induced by histamine on the effect of lithium on the retrieval of passive avoidance memory has been investigated. One- trail step- down passive avoidance task was used to assess memory in adult male NMRI mice. Post training administration of lithium (10 mg/kg) impaired the memory of passive avoidance task. Pre-test administration of the drug prevented the amnesia induced by lithium given after training, with maximum response at dose of 10 mg/kg. Sensitization was induced by once daily injections of histamine (20 /mouse) for 3 consecutive days and 5 day without the drug. Memory impairment by post-training lithium was restored better than non- sensitized mice. On the other hand, 3 days injections during sensitization of not only the histamine H1 receptor antagonist pyrilamine (40 /mouse), but also the histamine H2 receptor antagonist ranitidine (6.25 and 12.5 /mouse), prevented the restoration of memory impairment by pretest lithium (10 mg/kg). The results suggest that histamine sensitization affects the memory impairment induced by lithium and thus it is postulated that signaling cascade from histamine receptors may mediate the effects of lithium ion memory of passive avoidance task.

 
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