Paper Information

Title: 

THE EFFECT OF INTRA CEREBEROVENTRICULAR INJECTION OF LOSARTAN AND PRAZOSIN ON WATER INTAKE IN ADALT MALE WISTAR RATS

Type: POSTER
Author(s): PAKPOUR B.*,ORYAN SHAHRBANOU,ZARINDAST M.R.,NAVAEIAN M.
 
 *BBIOLOGY DEPT., ISLAMIC AZAD UNIVERSITY TEHRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Water intake is an important neuroendocrinological behavior for the control of body fluid homeostasis. The circumventricular structures and the lateral hypothalamuses (LH) have been shown to be important structures for water and electrolyt regulation. Evidence suggests that the brain has all the component of the rennin-angiotensin system which participates in the regulation of body fluid balance. a 1- adrenergic antagonist increased water intake. In the present study, the interaction of i.c.v injection of losartane (AT1 receptor antagonist) and prazosin (a1- adrenergic receptor antagonist) on water intake in water deprived adalt male rats, were investigated. For central administration, a guid cannula was implanted in the right lateral ventricle of rats, weighing between 200-250 gr. After recovery period, animals deprived of water for 24 h., and the drugss were administered. Then, rats were free to drink for 1h and the volume of water intake was measured. The results indieated that Losartane (45 µg/rat) decreased the rate of water intake, while Prazosin (0.1, 0.25 µg/rat) increased the rate of water intake, and Prazosin (0.25 µg/rat) attenuated the inhibitory response of Losartan (45 µg/rat). The present data suggest that angiotensinergic and adrenergic systems have an interaction in water intake mechanisms.

 
Keyword(s): 
 
Yearly Visit 37   tarjomyar
 
Latest on Blog
Enter SID Blog