Paper Information

Title:  PRESENCE OF GENOTOXICITY IN THE ABSENCE OF OXIDATIVE STRESS OR ACETYLCHOLINESTERASE INHIBITION IN BLOOD OF OCCUPATIONALLY EXPOSED SUBJECTS TO ORGANOPHOSPHORUS INSECTICIDES
Type: SPEECH
Author(s): SHADNIA SH.*,ABDOLLAHI M.,AZIZI E.,HOSSEINI ROUH ELAH,KHOUEI S.,FOULADDEL SH.,PAJOUMAND A.A.K.,JALALI N.
 
 *LOGHMAN HAKIM HOSPITAL POISONING CENTER, FACULTY OF MEDICINE, SHAHEED BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF TOXICOLOGY
Type of Seminar:  CONGRESS
Sponsor:  SOCIETY OF TOXICOLOGY
Date:  2004Volume 8
 
 
Abstract: 

The aim of this study was to evaluate the rate of genotoxicity and oxidative stress in organophosphorus pesticides formulating workers. In this survey the blood leukocytes and red blood cells of a group of 21 pesticide formulating workers and an equal number of control subjects were examined for genotoxicity and oxidative stress parameters. The mean comet tail length, mean comet length and mean head diameter were used to measure DNA damage. Lipid peroxidation, catalase and superoxide dismutase activities in erythrocytes were analyzed as biomarkers of oxidative stress. Results indicated that chronic exposure to organophosphorus pesticides resulted in increased activities of catalase and superoxide dismutase in erythrocytes. Level of lipid peroxidation and acetylcholinesterase activity did not show any difference between two groups. The results also indicated that chronic exposure to organophosphorus pesticides resulted in increased DNA damage. The present study suggests that human chronic exposure to organophosphorus pesticides may result in stimulated antioxidant enzymes and increased DNA damage.

 
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