Paper Information

Title: 

STUDY ON PROBABLE EFFECTS OF TOTAL EXTRACT OF AERIAL PARTS OF PHLOMIS COUCASICA AND PHLOMIS TUBEROSE IN TOLERANCE TO ANALGESIC EFFECTS OF MORPHINE

Type: POSTER
Author(s): PARVIZPOUR A.,DELAZAR A.,HABIBIASL B.,KHOUSHAMAD F.,EBRAHIMZADEH F.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: The purpose of this study was to investigate the probable effects of total extract of aerial parts of Phlomis coucasica and Phlomis tuberosa in inhibiting tolerance to analgesic effect of morphine. Substances such as phenolic compounds iridoid glycoside and flavonoids have been isolated from different species of Phlomis. Antinociceptive effect, anti-ulcerogenic and antioxidant activity have been reported for some of the Phlomis species. There is some evidence for the inhibition of NMDA receptors by iridoid of Phlomis. NMDA receptors have an important role in tolerance.
Methods: To investigate the effects of extracts from Phlomis in prevention of tolerance, different groups of male mice received: 1) saline (10 ml/kg, ip), 2) morphine (50 mg/kg, ip), 3) the vehicle of extract (saline + DMSO 10 ml/kg at a one to 25 ratio), and 4) different doses of extracts (50, 100, 200 mg/kg, ip) once a day for 4 days. The extract or its vehicle was administered half an hour before the injection of morphine every day. Tolerance to the analgesic effect of morphine (9 mg/kg, ip) was investigated in the fifth day in hot plate test.
Results: Administration of the total extract of Phlomis coucasica (50, 100, 200 mg/kg ip) significantly decreases tolerance to morphine (p<0.01, p<0.001, p<0.001 respectively) and Phlomis tuberose has similar significant effect on tolerance (p<0.05, p<0.01 and p<0.001 respectively). Conclusion: The results show that the above extracts reduce tolerance to analgesic effect of morphine.

 
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