Paper Information

Title: 

THE STUDY OF THE SHORT TERM EFFECTS OF MORPHINE WITHDRAWAL ON SPATIAL LEARNING AND MEMORY IN MORPHINE DEPENDENT RATS

Type: POSTER
Author(s): PEYVASTEGAN N.*,FARSHCHI B.,SAMADZADEH S.,POURMOTABED ALI,TOUHIDI ATEFEH,NEDAEI S.E.
 
 *DEPT. OF PHYSIOLOGY, SCHOOL OF MEDICINE, KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES, KERMANSHAH, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Back ground & aims: The effect of morphine dependence on spatial learning and memory is dependent to the methods of induction of dependency. It has been reported that oral morphine dependence facilitated formation of spatial learning and memory. In the current study we examined the short term effect of morphine elimination on spatial learning and memory in rats.
Methods: In this study rats received morphine sulfate (in dependent, withdrawal day 1 and withdrawal day 7 groups) or sucrose (in control groups) in drinking water for 30 consecutive days. Morris water maze (MWM) studies were performed either from day 26 to 30 during drug application (in control and dependent groups) or after morphine elimination (from day 1 to 5 in withdrawal day 1 or from day 7 to 11 in withdrawal day 7 groups). Spatial learning and memory parameters were subjected to the ANOVA.
Results: Data showed that formation of spatial learning in dependent and withdrawal groups is better than that in control ones.
Conclusion: Oral morphine dependence facilitated the formation of spatial learning in rats. This effect extended during short period of time after morphine elimination.

 
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