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Paper Information

Title: 

DIFFERENT EFFECTS OF TESTOSTERONE ON ACUTE AND CHRONIC PAIN IN MALE GONADECTOMIZED RATS

Type: POSTER
Author(s): JAMEI A.*,ZARIFKAR A.,SHARIATI M.
 
 *DEPT. OF PHYSIOLOGY, AZAD UNIVERSITY OF KAZEROON
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Nociception and behavioral responses to noxious stimuli are different in male and female animals. It seems that these differences are due to the effects of sex hormones on the pain mechanisms. The aim of the current study was to evaluate the effect of testosterone administration on nociception by formalin test in gonadectomized rats.
Materials and methods: In this research, 32 male Wistar rats, were divided into four groups (n=8). 1-The control rats without receiving any drug or surgical operation. 2-The sham - operated animals with surgical stress. 3-The gonadectomized rats, receiving 0.5 ml vehicle (olive oil ) i.p. 4-The gonadectomized rats, receiving testosterone enantate (6 mg/100 gr body weight in 0.5 ml vehicle i.p.). At the sixth day after gonadectomy operation, formalin test was done in all rats. Pain scores in formalin test were statistically analyzed by SPSS and t-test.
Results: The results showed that testosterone caused an increase in pain score in acute phase of formalin test in gonadectomized rats compared with sham-operated group (P<0.01). But, pain Score in chronic phase significantly was reduced in testosterone received rats (P<0.001).
Conclusions: It was concluded that testosterone increased nociception in acute phase through sensitizing the nociceptors. On the other hand anti-nociceptive effect of testosterone in chronic phase may be through central nervous system by interacting endogenous pain modulatory systems.

 
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