Paper Information

Title: 

INHIBITORY EFFECT OF ALLOPREGNANOLONE ON DIFFUSE TRAUMATIC BRAIN INJURY IN FEMALE RAT

Type: POSTER
Author(s): AHMAD MOULAEI L.*,KHAKSARI HADAD M.,SEPEHRI GH.R.,NAJAFIPOUR H.,MAHMOUDI MAHDI
 
 *KERMAN NEUROSCIENCE RESEARCH CENTER AND MEDICAL SCIENCES UNIVERSITY OF KERMAN, DEPARTMENT OF BIOCHEMISTRY OF KERMAN AND RAFSANJAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Backgrounds: Several studies have shown that the brain's response to injury is different between female and male, this finding might be related to Allopregnanolone. In the present study we investigated the role of Allopregnanolone in ovariectomized rat after diffuse traumatic brain injury (TBI).
Methods: Females rat were devided into 5 groups, of 10 animals in each as follows: 1group: control, 2group: trauma, 3group: sham, 4group: Vehicle, 5group: Allopregnanolone (ovariectomized rat, 4 mg/kg Allopregnanolone were injected, i.p 1 hour after TBI). Injury was induced using closed head injury model of Marmarou.
Findings: The results showed significant increase in brain water content in vehicle as compared to the control group (P<0.05).This comparison was also significant for Evans blue (P<0.001).But there wasn't any significant difference in water content between trauma and control groups. Animals were treated with 4mg/kg (IP) Allopregnolone showed a significant decrease in brain water and Evans blue content as compared to vehicle group (P<0.05, P<0.001).
Conclusion: Allopregnanolone plays an important role as a neuroprotective factor after traumatic brain injury, and this substance might be the cause of difference between male and female in brain's response.

 
Keyword(s): 
 
Yearly Visit 25   tarjomyar
 
Latest on Blog
Enter SID Blog