Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Title: 

ANTINOCICEPTIVE EFFECTS OF CARUM COPTICUM EXTRACT IN MICE

Type: POSTER
Author(s): AGHAEI AZITA*,RAKHSHANDEH HASAN,BAGHERI ZEYNAB
 
 *DEPT. OF PHARMACOLOGY, MASHHAD PHARMACOLOGICAL RESEARCH CENTER OF MEDICINAL PLANTS, GHAEM MEDICAL CENTER, MASHHAD UNIVERSITY OF MEDICAL SCIENCES, MASHHAD, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Carum copticum is a grassy, annual plant which grows in the east of India, Iran and Egypt with flowers and small brownish seeds. The seeds of this plant have an odor similar to thymol and have several therapeutic effects including diuretic, anti-vomiting, antibacterial, anti-asthma and analgesic.
Methods: In this study, the effect of carum copticum was studied on writhing test, a visceral pain model in mice. Dried seeds were extracted with 500 ml ethanol 70% using a suxhlet apparatus. Indomethacin (5mg/kg) was dissolved in normal saline and administered intraperitoneal (i.p) reference drug for comparison. The respective controls received only saline. The extract in doses (mg/kg) of 50, 75 and 100 and drug were administered intraperitoneally 30 min before acetic acid 0.6% (10mg/kg) (i.p) injection. Antinociception was recorded by counting the number of writhes after injection of acetic acid during three periods of 10 min. a writhe is indicated by abdominal constriction and stretching of at least one hind limb.
Results: The extract in doses (mg/kg) of 50 (number of writhing=13.7±10, p<0.001), 75 (number of writhing=16.7±13, p<0.001) and 100 (number of writhing=13.5±12, p<0.001) and indomethacin (number of writhing=12.7±7, p<0.001) induced significant reduction in writhing response as compared to control (number of writhing=72±17).
Conclusion: this study confirms the anti visceral pain properties of Carum copticum comparable to indomethcin and suggest a good place for it in antispasmodic therapies in human.

 
Keyword(s): 
 
 
Yearly Visit 0   tarjomyar
 
Latest on Blog
Enter SID Blog