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Paper Information

Title: 

THE INVESTIGATION OF THE EFFECT OF ENDOCANNABINOID′S PALMITOYLETHANOLAMIDE (PEA) ON PENTYLENTETRAZOL (PTZ) INDUCED KINDLING IN MALE RATS

Type: POSTER
Author(s): AGHAEI I.*,ROSTAMPOUR M.,MOTAMEDI F.,BABAEI PARVIN,KHAKPOUR B.,NADERI N.
 
 *DEPT.OF PHYSIOLOGY, SHAHEED BEHESHTI UNIVERSITY OF MEDICAL SCIENCES
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introdaction: In recent years, with discovering endocannabinoid system and its receptors (CB1 and CB2), antiepileptic effects of cannabinoids have been studied. Much of the reports show effects of CB1 agonist. There is no report on CB2 receptors. In this study we examined effects of natural ligand of CB2 (PEA).
Methods: In this study 50 wistar male rats were divided into 7 groups as: control, vehicle and treated groups that received PEA (1, 2.5, 5, 10 & 25 μg/Rat, ICV).Animals were anesthetized with Ketamin/Xylazine. A guide channula was fixed in left ventricle using sterotaxic apparatus. One week after recovery, kindlling procedures were initiated with injection of PTZ (37.5 mg/kg,i.p.) every 48 hours. Evaluatoin parametrs included first latency period (L.P.) of seizure, inverse initiation of fifth stage, duration of fifth stage and stages of seizure.
Results: This study showed that PEA in all dose compared with control and vehicle treated group increased L.P. (P<0.001). Inverse initiation of fifth stage with dose of 2.5 g and more (P<0.01) and also duration of fifth stage (P<0.001) and stages of seizure (P<0.005) was reduced.
Conclusion: These results indicate that it seems along with CB1 receptor, CB2 receptor might be involved in controlling seizures.

 
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