Paper Information

Title: 

COMPARISON OF THE ACUTE AND CHRONIC EFFECT OF B12 AND C VITAMINS ON THE ACUTE TRIGEMINAL PAIN IN RATS

Type: POSTER
Author(s): BABADOUST SANI E.*,MEHR M.,CHERAGHIAN S.,TAMADONFARD E.
 
 *DEPT OF NURSING, ISLAMIC AZAD UNIVERSITY OF URMIA
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: B group vitamins and vitamin C produce antinociception in the inflammatory pain tests. In this study the effects of acute and chronic intraperitoneal (IP) injection of B12 and C vitamins were compared in the acute trigeminal pain test of rats.
Methods: IP injection of B12 vitamin (0, 50, 250, 500 and 1000 µg/kg) and vitamin C (0, 2.5, 10, 25 and 50 mg/kg) at the 30 minutes and seven consecutive days before induction of acute trigeminal pain were performed. For induction of acute trigeminal pain, animals were placed on a wooden plate (50×50 cm). Ten minutes after adaptation period, one drop (40µl) of NaCl 5M was put on the surface of the eyeball and the number of eye wips performed with ipsilateral forepaw was counted during the first 30s.
Results: Acute ip injection of B12 and C vitamins had no effect on the pain response. Chronic ip injection of B12 vitamin at the doses of 250, 500 and 1000 µg/kg significantly (P<0.05) decreased the eye wips. Chronic ip injection of C vitamin produced non-significantly effect on pain.
Conclusion: By the results of this study, it is concluded that chronic application of B12 vitamin can reduce the acute pain response, where as C vitamin has no effect on the acute pain.

 
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