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Paper Information

Title: 

THE ROLE OF ANASTROZOLE (AN AROMATASE INHIBITOR) ON SPATIAL LEARNING AND MEMORY IN ADULT MALE RATS

Type: POSTER
Author(s): BABANEZHAD SOHEYLA*,NAGHDI N.,HAERI ROUHANI SEYED ALI
 
 *DEPARTMENT OF PHYSIOLOGY & PHARMACOLOGY, PASTEUR INSTITUTE OF IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: CA1 region of hippocampus in brain has an important role in learning and memory. Some reports have been shown that androgens like testosterone and its metabolites are present in high concentrations in different regions of brain especially in CA1. Testosterone and estrogen's receptors have also high density in this region. So it is suggested these neurohormones in CA1 have an important role in learning and memory. Some investigators believe that testosterone likely exert this effect via its metabolites especially estrogen. In this research we blocked conversion of testosterone to estrogen by using anastrozole to assess the path of testosterone's effectiveness on spatial learning and memory.
Methods: Adult male rats were bilaterally canulated into CA1 region of hippocampus and divided into 2 groups and their spatial memory has been assessed by using Morris water maze. One group were injected bilaterally DMSO 0.5μl as control group and another anastrozole (An) (0.5 µg/0.5 μl). Each 2 groups were trained in 2 blocks with 4 trials 25-30 min after injection. Next day probe and visible platform test were done.
Results: statistical analysis showed that there were no significant differences between the control and experimental groups in acquisition while in retention test, the percentage of swimming path spent in the target quadrant for (An) group significantly increased as compared with control group. This evidence indicates that Anastrozole may have a reinforcing effect on consolidation or retrieval not acquisition of spatial learning and memory.
Conclusion: Anastrozole as an aromatase inhibitor could improve spatial learning and memory so it seems that testosterone-induced impairment of spatial memory that previously was investigated may be via its aromatization to estrogen.   

 
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