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Paper Information

Title: 

EFFECT OF TAMOXIFEN ON THE ACQUISITION OF A CONDITIONED PLACE PREFERENCE PARADIGM IN MALE AND FEMALE MICE

Type: POSTER
Author(s): BASEDA Z.*,ESMAEILI B.,DEHPOUR A.R.
 
 *DEPARTMENT OF PHARMACOLOGY, SCHOOL OF MEDICINE, MEDICAL SCIENCES/UNIVERSITY OF TEHRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Objectives: Selective estrogen receptor modulators (SERMs) are compounds that display both agonist and antagonist effects on estrogen receptors in a tissue-selective manner. Tamoxifen (TMX) is a SERM which is well characterized with regards to its effects on breast cancer in postmenopausal women. It has been shown that TMX can significantly increase caudate nucleus DA release in mice, which is a part of brain reward system. The major goal of this study is to assess the effect of TMX on brain reward system, using a conditioned place preference paradigm. Difference of this effect between male and female mice is also considered.
Methods: 64 Adult Male and female NMRI mice were randomized into 8 equal groups and TMX was injected subcutaneously (0, 10, 20, or 50 mg/Kg) to evaluate the induction of conditioned place preference or aversion (CPP or CPA) using an unbiased conditioned place preference procedure.
Results: Different doses of TMX failed to induce neither CPP nor CPA in either group, and no significant difference was found between the two sexes.
Conclusion: Our results, in favor of other recent findings, suggest that TMX acts as a partial agonist of estrogen receptor in reward-related circuits of mice brain. Furthermore, other possible mechanisms, such as perceptual and learning impairments due to acute administration of TMX are also considered
.

 
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