Paper Information

Title: 

THE PROTECTIVE EFFECT OF GENISTEIN IN EXPERIMENTAL MODEL OF PARKINSON DISEASE IN MALE RATS: HISTOCHEMICAL AND BEHAVIORAL STUDY

Type: POSTER
Author(s): BALUCHNEJADMOJARAD TOURANDOKHT,ROGHANI MEHRDAD,BAGHERI MARYAM*
 
 *PHYSIOLOGY GROUP, MEDICAL BASIC SCIENCE, IRAN UNIVERSITY OF MEDICAL SCIENCE, HEMMAT HIGHWAY, TEHRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Parkinson disease is one of the most common neurodegenerative diseases involving the degeneration of dopaminergic neurons in the substantia nigra. Oxidative stress and increased lipid peroxidation have been reported as the main causes of dopmainergic neurons degeneration in Parkinson disease. Regarding to antioxidant effect of genistein, this study was conducted to investigate the protective effect of genistein on experimental model of Parkinson disease. For this purpose, unilateral intrastriatal 6-hydroxy dopamine lesioned rats were intraperitoneally pretreated with genistein (10mg/kg) one hour before surgery. Apomorphine-induced rotations pre-and post surgery after 2 weeks and the number of SNC neurons 14 days after surgery were measured. The results showed that there is a reduction controversive apomorphine-induced rotation in genistein pretreated lesioned group on compared to the unpretreated lesioned group. On the other hands, pretreatment with genistein prevent the degradation of neurons in SNC of lesioned group. Taken together, these results showed that, administration of genistein could attenuate the drug-induced behavioral and histological abnormalities in this model of Parkinson disease.

 
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