Paper Information

Title:  COMPARATIVE EFFECTS OF LATANOPROST (XALATAN) AND TIMOLOL IN PATIENTS WITH OPEN-ANGLE GLAUCOMA
Type: POSTER
Author(s): ALI PANAHI R.,MORSALI M.,SAYAHMELI SARA,SAYAHMELI SIMA
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

PURPOSE: To compare, in paired eyes of open-angle glaucoma patients, hydrodynamic and visual changes after 1 month of topical latanoprost in one eye and timolol in the other.
DESIGN: Single-center, institutional randomized clinical trial.
METHODS: After completing a washout period off all topical medication,32  adults (mean age 50-70 years) with bilateral open-angle glaucoma underwent morning (8 to 10 AM) and afternoon (1 to 3 PM) measurements of intraocular pressure (IOP), Humphrey 32-2 perimetry in both eyes. Each then started Timolol 1% in one randomly assigned eye and latanoprost 0.005% (Xalatan) in the other. Timolol was administered at 8 AM and 8 PM and latanoprost at 8PM with placebo at 8AM, both from masked bottles. After 28 days, differences were determined for each measured variable by two-tailed paired t test.
RESULTS: Starting from similar baseline IOP levels, after 1 month of treatment, the mean morning IOP values differed according to the topical agent received (14+- 5mm Hg for latanoprost vs 18.3+-4m Hg for timolol; P .005). These morning pressures were 1.6 mm Hg lower than baseline in the eyes receiving latanoprost (P<.0001), and 1.6 mm Hg lower in timolol treated eyes (P  .002). Humphrey perimetry and cup disk remained stable with both eyedrops.
CONCLUSIONS: Both latanoprost andtimolol produced significant reductions in IOP and perimacular visual function. Latanoprost once daily produced IOP reduction nearly one fold greater than those obtained with timolol twice daily. Both drugs have proven to be safe. Benign alterations in iris color and elongation of eyelashes have been observed in a small proportion of patients with Latanoprost (Xalatan).

 
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