Background: A little of Previous investigation show that the seed of the Foeniculum vulgar (FV) have many medical effects. The aim of this work is assessment the role of Aquinus extract of seed of FV on acute and chronic pain in formalin test in mice
Material and Methods: In this study male albino mice (25-30 gr.) in 6 groups (n=42), were used. FV (100, 200, 500 and 1000 mg/kg) and saline were injected 30 min before formalin test. Indexes of signs were licking and foot elevation for assessment of acute pain (5 min) and chronic pain (15-40 min) after injection of formalin 5% (25µl) in right paw. Findings indicate that FV has analgesia effect in duration of acute and chronic phases in compare with control and saline groups.
Results: In this study results indicated that Fv has analgesic effect on pain in both doses in acute and chronic phases (P<0.05).
Conclusion: Finding above showed that FV can modulate acute and chronic pain. Further research is required to determine the mechanisms by which FV has an inhibitory effect on pain sensation.