Paper Information

Title: 

AN INVESTIGATION OF THE EUCALYPTUS GLOBULUS EXTRACT ON ATROPINE-INDUCED HYPERTHERMIA IN MICE

Type: POSTER
Author(s): ABEDINZADEH M.,HEDAYATIFAR F.,HASHEMI M.,MOGHADAMNIA ALI AKBAR
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Eucalyptus has been used for hundreds of years as traditional remedies. In some ancient sources, it had been called as fever tree. This study was done to determine the effects of eucalyptus extract on core body temperature in mice.
Methods: The mice were divided into 3 groups: group 1 (200 mg/kg of extract, ip), group 2 (400 mg/kg of extract, ip) and group 3 (Atropine 10mg/kg, ip, 15 min before test). Groups 1 and 2 of the mice were injected atropine (10mg/kg) as pretreatment 15 min before receiving extracts. After 15 minutes of the latest injection, the body temperature was measured by a sensitive rectal probe every 10 up to 90 minutes.
Results: There was no statistical significant difference at the baseline and between group1 and 2. From the 15 minutes after eucalyptus injection, there was a significant difference between data of eucalyptus receiving groups and group 3 (p<0.0001). The maximum mean ±SD (1.70±0.98) of reduction of the temperature was seen in group 1 at 105 minute. The trend of the temperature reduction in the group1 and 2 compared with group 3 (atropine alone) were considerable up to 105 min.
Conclusion: According to this study, eucalyptus extract could reduce atropine-induced hyperthermia. There was no significant difference between various doses of the extracts in this investigation.

 
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