Paper Information

Title: 

SURVEY OF EFFECTS OF LIQUID EXTRACT OF WALNUT LEAVE (JUGLANS REGIA) ON GLUCOSE AND LIPIDS VALUE IN DIABETIC RATS

Type: POSTER
Author(s): KOMEYLI GH.R.*,MIRI MOGHADAM E.
 
 *DEPARTMENT OF PHYSIOLOGY, FACULTY OF MEDICINE, ZAHEDAN UNIVERSITY OF MEDICAL SCIENCES
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Background: Diabetes mellitus is a disease that 6.6% in world and about 3 million people in Iran suffer from this disease. This illness induced with different causes such as disturbance of beta cells in pancreatic islet (IDDM). From very year’s ego, administration of therapeutic herbal in medicine is custom. In present study, the effects of liquid extract of Walnut leave on glucose and lipids in animal model were considered.
Methods: 20 adult male Winster rats (200 – 250g) were chosen and divided to two groups (case and control) randomly and housed in single cages. In first time, blood sample were taken for glucose and lipids (cholesterol, triglyceride, LDL and HDL) measurement. Then in case group animal, diabetes was induced with stereptozocine (60 mg/kg) and control group given normal saline intra
pritoneally. Water and food usage in animals was measured in duration of experiment. After of one week, sings of diabetes such as polyphagia, polyureia and polydipsia was appeared in case group and determined with glucose measurement. Then case group received liquid extract of Walnut leave (400 mg/kg) intra gastric for four week and control group received normal saline. Finally, blood sample was taken and glucose and lipids were measured again.
Results: administration of Walnut leave extract decreased glucose level in diabetic rats significantly (P<0.05, although ever since was higher than control group) but not effect on lipid values.
Conclusion: It seems that effects of Walnut extract on lipid metabolism in diabetes requirements to more experiences.

 
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