Paper Information

Title: 

THE STUDY OF ANTIDIABETIC EFFECTS OF AVICENNIA MARINA FRUIT EXTRACT IN MALE RAT

Type: POSTER
Author(s): KAMAEI L.*,FATHI MOGHADAM H.,MOKHTARI M.,AHANGARPOUR A.
 
 *DEPT.OF BIOLOGY, AZAD UNIVERSITY OF KAZERON, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: In the traditional and modern medicine different traputics have been recommended for diabetes Mellitus. Avicennia marina (Forssk) Vierh is a type of mangrove plants which can grow in intertidal zone of sea. In this study effects of Avicennia marina fruit Aqueous-aqueous-alcoholic extracts diabetic rat were used.
Methods: 45 male rats were divided into 9 groups (n=5) control group and diabeties groups. Diabeties groups are diabetes, diabetes control (given 0/9% normal saline) and 6 treated extracts groups. Diabetes induced by intrapeiteal injection of 60 mg/kg body weight streptozotocin in rats. Maceration was used as the extraction method. The rats with blood glucose above 250 mg/dl (using glucometer), as well as other diabetic sign polydipsia, polyurea and polyphagia were selected for the experiment  Aqueous and aqueous-alcoholic fruits Avicennia Marina extracts at an oral dose of either 30, 60, 120 mg/kg daily for three consecutive days. Twenty-four hours after the last treatment rats, blood was collected from heart. Blood glucose concentration levels of rats were determined by glucose oxidase method. Insulin levels were determined by Enzyme-linred immunosorbent assay (Elisa) method.
Results: Over results shown that both aqueous and aqueous-alcoholic fruit extracts could decrease the mean blood glucose of diabetic rats in comparisons with diabetic control gruop. However, it has shown that a significant increases in the serum Insulin levels. To determine the LD50, 48 hours after the administration of the extracts no mortality and morbidity effect was observed. In diabetic rats, no increase was found in the final body weights.
Conclusion: In this study were shown effects of decreases blood glucose by Avicennia marina fruit extracts in diabetic rats.

 
Keyword(s): 
 
Yearly Visit 16   tarjomyar
 
Latest on Blog
Enter SID Blog