Paper Information

Title: 

THE EFFECTS OF AQUEOUS EXTRACT OF TEUCRIUM POLIUM L. ON GASTRIC MOTILITY IN BASAL AND VAGAL-STIMULATED CONDITIONS

Type: POSTER
Author(s): KESHAVARZ Z.*,NIAZMAND SAEID,HAJZADEH M.A.R.
 
 *DEPT OF PHYSIOLOGY, MEDICAL SCHOOL, MUMS, MASHHAD
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Objective: The aim of this study is investigating the effects of aqueous extract of Teucrium polium L. on rat gastric motility in basal and vagal-stimulated conditions.
Methods: Twenty four Wistar rats weighed 200-250g were randomly divided into groups of 12 as case and control. Animals were anesthetized by sodium thiopental (50 mg/kg, ip) and tracheostomy, laparatomy and gastrodeodenostomy were prepared for each rat. Aqueous extract of the plant were prepared by maceration and 1ml of 20, 40 and 80 mg/kg doses were introduced into the stomach of each rat in case group and the same volume of saline in control group. Gastric motility was measured by pressure transducer. The results were analyzed by t-test and multivariate analysis, p<0.05 were considered to be significant.
Results: Tucrium polium aqueous extract has decreased frequency  of contraction in case VS  control group in both conditions, but the intra gastric pressure decreased in case group  although has not insignificant encompassing with control group. Tucrium polium aqueous extract effects on contraction frequency, showed time-response manner only in basal condition, its effects on intra gastric pressure in basal condition in presence of 20 mg/kg and in vagal stimulation in presence of 40 mg/kg dose of the extract were time- response. Intra gastric pressure in vagal stimulation was dose dependent, but contraction frequency was not dose dependent, in both conditions.
Conclusion: Intra gastric pressure with 3 different doses of aqueous extract of Teucrium polium between control and case groups was insignificant in two conditions but the frequency contraction was significantly decreased in both conditions.

 
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