Paper Information

Title: 

EFFECTS OF VITAMIN E AND GINGER ON HIPPOCAMP OF DIABETIC RATS

Type: POSTER
Author(s): KARIMIPOUR MOJTABA,SHIRPOUR A.R.,ZIRAK JAVANMARD M.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Diabetes is a common endocrine disorder and causes memory and learning complications. The aim of this study was to investigate the effects of vitamin E and ginger (as antioxidants) on the hippocamp of diabetic rats.
methods: 32 adults male rats, weighting 250±20, were randomly selected and divided into 4 groups as follow: control group, diabetic (induced by 60mg/kg STZ) non-treated group, diabetic group treated by vitamin E (300 mg/day) and diabetic group treated by ginger (5% of their daily consumed food). After 8 weeks, all animal sacrificed and removed hippocamp and fixed in 10% formalin and obtained slides with hematoxiline eosin staining and number of the pyramidal cells of hippocamp studied by means of eye piece.
Results: The results showed that number of the pyramidal cells in diabetic rats decreased in compared with control group, but there were no significant difference between control group and treated diabetic groups.
Conclusion: The results of this study demonstrated that vitamin E and ginger as antioxidants prevented pathologic altrations in hippocamp induced by diabetes.

 
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