Paper Information

Title: 

THE EFFECT OF SAFFRON EXTRACT ON SPATIAL LEARNING AND MEMORY IN RATS

Type: POSTER
Author(s): GHADAMI S.*,GHADAMI M.R.,HAGHIGHIZAD H.,POURMOTABED ALI,SAHRAEI HEDAYAT,KAMALNEZHAD MOHAMMAD
 
 *DEPARTMENT OF PHYSIOLOGY, KERMANSHAH UNIVERSITY OF MEDICAL SCIENCE, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Background: Crocus sativus L. that commonly known as saffron is an important plant in folk medicine in Iran. Modern pharmacological studies have demonstrated that saffron extract have antitumor effects, radical scavenger properties and hypolipaemic effects. In addition, it has recently been found it could be useful in neurodegenerative disorder accompanying memory impairment. In this study, we investigated the effect of saffron extract on spatial learning and memory in rat using Morris water maze (MWM).
Methods: in the current study, male rats received saffron extract (50 mg/kg, i.p.) or saline for 5 consecutive days. 30 minutes after injection, spatial learning and memory parameters in the some days in (MWM) were tested and subjected to the ANOVA and followed by Tukey test for multiple comparisons.
Results: Our results showed that in the saffron extract group, the time to find platform (escape latency) and distance swimming significantly decreased compared with saline group. Conclusion: The results indicated that saffron extract has ameliorating effects on spatial performance. It could be concluded that saffron extract affects on receptors that involve in learning and memory and improves learning process.

 
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