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Paper Information

Title: 

EFFECTS OF CROCUS SATIVUS STIGMA EXTRACT AND ITS CONSTITUENTS, CROCIN AND SAFRANAL, ON INTACT MEMORY AND SCOPOLAMINE-INDUCED LEARNING DEFICITS IN RATS PERFORMING THE MORRIS WATER MAZE TASK

Type: POSTER
Author(s): ZIAEI T.,HOSSEINZADEH HOSSEIN
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

In this study, the effects of aqueous extract of Crocus sativus stigma and its constituents, safranal and crocin, were studied on intact memory and scopolamine-induced learning deficits in rats performing the Morris water maze task. The extract and its constituents were injected intraperitoneally to rats one h before training for 5 consecutive days. During the training period, four trials were carried out each day. on the 5th day of the experiment, the locomotor activity was assesed usig open field test. Generally, the aqueous extract (0.0025-0.56 g/kg) of stigma did not decrease the latency time to find the platform. Only, a dose of 0.005 g/kg reduced the latency time during five days. Crocin (50 and 200 mg/kg), also did not change the latency time. Safranal (0.2-0.75 ml/kg) increased the time to find the platform. The effects of the extract, crocin and safranal were also evaluated on hyoscine (1 and 500 mg/kg)-induced learning deficits in rats. The stigma extract and crocin reduced the deficiets effect of hyoscine (in low and hiegh dose) on memory. Safranal (except a dose of 0.2 ml kg) did not decreased the effect of hyoscine on memory. In the open field activity test, the aqueous extract, crocin and safranal reduced total activity. The co-administration of these agents with hyocine significantly compensated the reduction of locomotor activity in hyosine group alone. On the basis of these results, the Crocus sativus stigma aqueous extract, crocin and safranal did not have effect on intact memory but the extract and crocin inhibited the hyoscine impaired acquisition/performance activity. These agents can be potentially introduce as new drugs in the treatment of cognitive dysfunctions such as Alzheimer's disease.

 
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