Paper Information

Title: 

ANTIOXIDANT ACTIVITY OF FLAVONOIDAL FRACTIONS OF ZATARIA MULTIFLORA BOISS

Type: POSTER
Author(s): MOJAB F.*,NIKAVAR B.,TABATABAEI S.A.,GORJINEZHAD B.
 
 *PHARMACEUTICAL SCIENCES RESEARCH CENTER, SHAHID BEHESHTY OF MEDICAL UNIVERSITY, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Free radicals especially oxygen radicals play an important role in the development of molecular damage, cell injury and pathological events. A large amount of researches has been carried out to find antioxidant drugs, which participate as radical scavenger in living organism. Currently there is an increasing interest in the antioxidant activity of natural compounds. Zataria multiflora is rich in constituents that are known to be effective radical scavengers. Zataria multiflora is used in Iranian traditional medicine for different properties, such as antitussive, flatulent and antispasmodic.
Methods: This study was designed to examine the in vitro free radical scavenging activities of flavonoid fractions that obtained from column chromatography and total extract from aerial parts of Zataria multiflora found in Iran. The herb was purchased from market in Tehran in spring 2005. The in-vitro free radical scavenging activities were spectrophotometrically evaluated by quantitive DPPH assay. The positive control used was flavonoid Rutin.
Results: The free radical scavenging activity of each of fractions and extract was expressed as an IC50% value and calculated from concentration-response curve and it calculated by prism software. The results indicate that 4th fraction has a very potent free radical scavenging activity (with IC50 16g/ml).
Conclusion: According to these results, it is suggested that 4th fraction further investigated for isolation of components and assay of these.

 
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