Paper Information

Title: 

INVESTIGATION OF ANALGESIC EFFECTS OF OCIMUM BASILICUM L. ESSENTIAL OIL IN MALE AND FEMALE MICE

Type: POSTER
Author(s): HAJI MAHDIPOUR H.*,SAHEBGHARANI M.,AGHA JAN SHAKERI N.,HOSSEINI Z.,BAYRAMI F.,YOUSEFI S.
 
 *DEPARTMENT OF HERBAL DRUGS, FOOD AND DRUG CONTROL LABORATORY, TEHRAN, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Plants are known to be a rich source of naturally occurring antinociceptive substances. One of the plants that is used in traditional medicine for pain is Ocimum basilicum L. but no pharmacological studies have been done on analgesic effects of the plant. In the present investigation, we decided to evaluate the effects of essential oil of Ocimum basilicum L. aerial parts in one of the classic pharmacological test for nociception (formalin test) in male and female Swiss mice.
Method: In order to do the formalin test, different dosages of the plant essential oil were injected to the mice (i.p.) 5min before injection of formalin (0.5%, 20μl) and mice reactions were scored.
Results:  Essential oil of the plant did not produce any analgesia in acute phase (0-15min) but in chronic phase (15-50), at dosages 1 and 5 mg/kg showed antinociception in female mice however in male mice, only dosage 1mg/kg produced analgesia. Plant essential oil at higher dosages 5mg/kg stimulated mice. Furthermore, treatment with naloxone (2mg/kg) did not reverse analgesia in both sex indicating that in analgesic effects of the plant essential oil, the opioid system is not involve. Essential oil of the plant produced more inhibition in female mice compare to male mice as well.
Conclusion: Essential oil of Ocimum basilicum L. has analgesic effects in male and female mice without involving opioid system. Further more, antinociception effect of the plant essential oil in female mice, is more powerful than male mice.

 
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