Paper Information

Title:  NERVE AGENTS AND ROLE OF CARBAMATES FOR PROPHYLAXY
Type: SPEECH
Author(s): SHOHRATI M.*,KHOUSHBATEN A.,PANAHI U.
 
 *BAQIATALLAH UNIVERSITY OF MEDICAL SCIENCES, RESEARCH CENTER FOR CHEMICAL INJURIES
 
Name of Seminar: IRANIAN CONGRESS OF TOXICOLOGY
Type of Seminar:  CONGRESS
Sponsor:  SOCIETY OF TOXICOLOGY
Date:  2004Volume 8
 
 
Abstract: 

The chemical structure of Nerve Agent is similar to organophosphates, the first organophosphate was synthesized at 1854 in France and the other organophosphates and Nerve Agents was developed at 1930 in German. The Nerve Agents are esters of Acid Alkyl phosphonic that divided in to G and V groups. The toxicity of V agents is greater than G agents and stability of V agents is greater than G agents in the environment. Mechanism of action of Nerve Agents is inhibition of acetylcholin estrase and accumulation of acetylcholine and therefore we can see muscarinic and nicotinic effects in human body. Scince complex of Nerve Agents and ACH-E is erriversible and the Aging phenomena occurred after two minutes with soman, prophylaxy is better than treatment. Pyrisostigmine is a carbamates compound with reversible cholinesterase inhibition and short half life that inhibit the activity of Ach-E for a few hours. Pyridostigmine was used during the gulf war by American troops as a pretreatment drug to protect troops from the harmful effects of nerve agents. The dose of this drug was 30mg every 8 hours and adverse effects that had seen gastrointestinal effects at 50%, genicourinary effects at 5-30% and only less than 1% of troops discontinuance the use of drug because of severe adverse effects.

 
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