Paper Information

Title:  COMPARATIVE HYPNOTIC EFFECT OF LETTUCE EXTRACTS AND DIAZEPAM IN MICE
Type: POSTER
Author(s): RAKHSHANDEH HASAN,AGHAEI AZITA,RAKHSHANDEH HAKIMEH*
 
 *PHARMACY SCHOOL, MEDICAL SCIENCE UNIVERSITY OF KERMAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: Lettuce is a grassy, annual plant which has several therapeutic effects including anti-convulse, anti-inflammatory and diuretic. In traditional medicine hypnotic effect of lettuce is also suggested. In this study, the hypnotic effect of the extracts of was investigated in mice.
Methods: hypnotic method was based on potentiation of pentobarbital induced sleeping time (min) by extracts. The ethanolic 70% suxhelat extract of lettuce, the ethanolic 50% macerated extract of lettuce leaves and the ethanolic 50% macerated extract of lettuce stock, with 400mg/kg dosage were injected intrapritonealy in comparison with diazepam (3mg/kg) as the positive control and saline (10ml/kg) as the negative control. Thirty min after injection of extracts, pentobarbital (30mg/kg) was injected and the increase in the sleeping time (min) due to the extracts was recorded.
Results: the results showed that the ethanolic 70% suxhelat extract of lettuce (sleeping time=86.1±29, P<0.001) and the ethanolic 50% macerated extract of lettuce leaves (sleeping time=47.8±14.6, P<0.01) significantly prolonged the pentobarbital induced sleeping time as compared to control group (sleepingtime= 20.2±1.3). Sleeping time in animals receiving ethanolic 50% macerated extract of lettuce stock (sleeping time=33.5±9.4, P>0.05), hasn't significant difference with negative control. Even Sleeping time in animals receiving ethanolic 70% suxhelat extract of lettuce was significantly more than positive control which received diazepam (sleeping time=38.8±3.8, P<0.001).
Conclusion: the results of this study showed hypnotic effect of Lettuce.

 
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