Paper Information

Title:  STUDYING ROLE OF ASCORBATE ON PREVENTION OF MORPHINE ADDICTION IN RATS
Type: POSTER
Author(s): RAFATI A.*,DASHT M.H.,MORSHEDI A.
 
 *HERBAL MEDICINE RESEARCH CENTER, SHAHID SADUGHI MEDICAL UNIVERSITY YAZD, IRAN
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Today, addiction is one of the most important social problems. Morphine is an addictive drug which causes several alterations in human body. Both acute and chronic administration of morphine increase releasing of dopamine which leads to dependence and tolerance to it. One of the most important factors that prevent addicted people from abandonment is painful symptoms of withdrawal syndrome. So finding a method to decrease withdrawal symptoms can be a good protocol to defeat this challenge. Since ascorbate which is released from glutaminergic neurons is a modulator of central dopaminerigic and glutaminergic transmissions, we decided to study role of it on prevention and decreasing physical dependence of morphine addiction in rats .In this study we evaluated withdrawal symptoms (e.g. jumping, wet dog shaking) after naloxane injection in sham (Normal saline IP injection), control (Fixed doses of morphine IP injection) and test (500 mg/kg ascorbate IP injection before morphine daily) groups. Our results suggested that ascorbate could interact directly with dopaminerigic system and reduce both tendency to morphine and physical dependence of it. So we may be able to use it as a potent agent in treatment of addicts.

 
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