Paper Information

Title: 

TOXIC EFFECTS OF CURCUMA LONGA EXTRACT ON LIVER AND KIDNEY IN MICE

Type: POSTER
Author(s): KHOURSANDI L.S.,OURAZIZADEH M.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Introduction: In the recent years, many medicinal properties of Curcuma longa have been shown including: antioxidant, antitumor and antiinflammatory effects. Most of the studies on cytoprotective effect by high and single dose of Curcuma longa extract have been reported and toxicity of this product on various tissues has not been evaluated in chronic prescription. In this study the toxicity effects of Curcuma longa on liver and kidney in mice have been evaluated.
Methods: 40 NMRI male mice were randomly divided into 4 groups. Normal saline was given to the control group (A). Test groups (T1-T3) treated with Curcuma longa extract in doses %0.5, %1 and %2 of diet daily for 21 days. The jugular arteries were cut for biochemical tests in 22ND day. Then liver and kidney removed and placed in %10 formalin solution for histopathological studies.
Results: The liver of mice received 2% Curcuma longa (T3) showed necrosis and lipid peroxidation and ALT (Alanine Transferase) and AST (aspartate Transferase) have been elevated. There weren’t any histopathological changes in kidneys and also the BUN (Blood Urea Nitrogen) and Cr (Creatinine) levels did not show alterations.
Conclusion: It appears that Curcuma longa is involved in mouse hepatotoxicity and not involved in nephrotoxicity.

 
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