Paper Information

Title: 

EFFECT OF CAMOMILE (ANTHEMIS NOBILIS) AQUEOUS-ALCOHOLIC EXTRACT ON FEMALE RATS ESTROGEN HORMONE (POLYCYSTIC OVARY MODEL)

Type: POSTER
Author(s): AMIR ZARGAR A.,ZAFARI ZANGENEH FARIDEH,AHANGARPOUR A.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

Polycystic ovary syndrome (Pcos) with complex pathology and etiology is a common condition characterized menstrual abnormalities in Iranian teenage girls and middle life that have clinical or biochemical features of hyperandrogenisis , hirsutism, cardiovascular disease, diabet mellitus and infertility. Experimental induction of a polycystic ovarian syndrome (Pcos) in rodents by the administration of a single dose of estradiol valerate (ev) and camomile (Anthemis Nobilis) aqueous-alcoholic extract content components that its treatment can help in decrease Pcos sign and devising therapeutical strategies for ovary. The effect of Camomile extract examind in this study because of some reports that have shown activation of peripheral sympathetic nerves of ovary resulting in imbalance of esterogen, and also the phytoesterogen in Cammomile and its antiaromatase effect.
Materia & Drugs: 42 rats weighing 200-220gr were obtained from animals center Ahvaz university Medical sciences. Animals showing 4-day cycle were used for the experiments. A pcos condition was induced by the administration of Estradiol valerate (2ml/rat) diluted in 0.2ml corn oil (single dose). After 45-60 days the follicular cysts as well established. The crystal of alcoholic-water extract 0f Camomile I.P. injected in four dose (12.5, 25, 50 and 75 mg /day) for ten days.
Results: Histological investigations show high dose of extract (75mg/day) with large cyst and sever inflammation in uterus hornes, and in dose 50 mg/day there was small cyst and inflammation, Hormone measure, estrogen hormone showed that in 50 mg dose of extract was decreased (P<0.029).

 
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