Paper Information

Title: 

STUDY ON IN VITRO ANTIFUNGAL ACTIVITY OF KETOCONAZOLE, ALLIUM CEPA (ONION) AND ALLIUM SATIVUM (GARLIC) AGAINST SOME PATHOGENIC YEASTS AND DERMATOPHYTES

Type: POSTER
Author(s): AMIR RAJAB N.,SHAMS M.,SHOKOUH AMIRI M.R.,MOGHADASI B.
 
 
 
Name of Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Type of Seminar:  CONGRESS
Sponsor:  PHYSIOLOGY AND PHARMACOLOGY SOCIETY, MASHHAD UNIVERSITY OF MEDICAL SCIENCE
Date:  2007Volume 18
 
 
Abstract: 

In recently years, antifungal resistance in the treatment of related fungal disorders such as candidiasis, dermatophytosis etc … have seen frequently.  In this study, In vitro antifungal effects of two plant extracts onion and garlic against different strains of Candida, Malassezia furfur and dermatophytes investigated and comparative with antifungal activity of ketoconazole
method: Agar dilution method was used for determining of above mentioned compounds. The fungi were cultured on sabouraud dextrose agar in the presence of different concentrations of selected compounds and determinated Minimum Inhibitory Concentration (MIC) of these compounds, separately.
Results: All compounds were inhibited the grouth of Candida species, Malassezia furfur and dermatophytes in a dose - dependent manner. MIC amounts of ketoconazole, onion and garlic extracts for all examined fungi were determined in the range of 0.016-128 (µg/ml), 0.016-32 (mg/ml) and 0.002-2 (mg/ml), separately.
Discussion: On the whole, ketoconazole show the most antifungal effects againsts Epidermophyton floccosum however onion and garlic showed antifungal activities against Candida albicans, dermatophytes and Malassezia furfur, respectively. With respect to the high antifungal activity of onion and garlic extracts, finding of active antifungal fractions of these extracts and substitution of synthetic antifungal drugs with natural compounds is recommended.

 
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